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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 49-year-old man presents to his physician with a 3-day acute attack of gout in four joints of the right foot. The patient has a history of at least three previous gout attacks; in one, a joint aspirate was positive for urate crystals. His history also includes type 2 diabetes mellitus and two calcium oxalate kidney stones.
Laboratory values include creatinine 3.1 mg/dL, uric acid 11.7 mg/dL, and A1C 6.8%. The patient is allergic to aspirin. Vital signs are BP135/82mm Hg and HR 90 bpm and regular.
Current medications are glipizide 10 mg daily and enalapril 20 mg daily.
Which short-term regimen is most appropriate for treating this patient's gout?

A) Prednisone 40 mg daily
B) Indomethacin 50 mg three times daily
C) Colchicine 0.6 mg hourly
D) Celecoxib 200 mg daily

2. A 53-year-old patient with an 8-year history of diabetes is currently taking glipizide 10 mg twice daily before breakfast and supper. The patient weighs 85 kg and reports a 4.5 kg weight gain in the last year. Laboratory results are:
Creatinine: 1.2 mg/dL
A1C: 8.5%
What is the most appropriate recommendation at this time for improved diabetes control?

A) Continue with glipizide and add metformin.
B) Increase glipizide to 20 mg twice daily.
C) Change glipizide to insulin.
D) Change glipizide to metformin.

3. Which of the following pharmacoeconomic analyses incorporates patient preferences regarding health?

A) Cost-utility
B) Cost-benefit
C) Cost-effectiveness
D) Cost-minimization

4. A 21-year-old patient with leukemia is admitted to the hospital with a temperature of 38.9°C and a nonproductive cough 8 days after induction chemotherapy completion. Laboratory tests show a WBC count of 1,000 cells/ul (10% segmented neutrophils, 0% bands, and 90% lymphocytes) and a platelet count of 60,000 cells/uL. Chest X-ray reveals a small left lower lobe infiltrate. Blood, urine, and sputum cultures are obtained. What should be the recommendation for initial management?

A) Hold antibiotics until Culture results are available.
B) Initiate amphotericin, ceftazidime, and gentamicin.
C) Initiate fluconazole, vancomycin, and imipenem.
D) Initiate cefepime, Vancomycin, and tobramycin.

5. Post myocardial infarction, a patient's cardiac profile and serum chemistry results show the following values:
Heart rate: 120 bpm
Blood pressure: 80/40 mm Hg
Pulmonary capillary Wedge pressure: 6 mm Hg
Right atrial pressure: 2 mm Hg
Cardiac index: 2.3 L/min/m2
Sodium: 136 mEq/L
Potassium: 4.2 mEq/L
Chloride: 98 mEq/L
Bicarbonate: 22 mEq/L
Blood urea nitrogen: 25 mg/dL
Creatinine: 1.0 mg/dL
Glucose: 110 mg/dL
Which one of the following therapeutic regimens is most appropriate for the initial treatment of this patient?

A) Nitroprusside 2 mcg/kg/min
B) Dopamine 15 mcg/kg/min
C) Furosemide 40 mg intravenous push
D) Normal saline 500 mL/h

Solutions: